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SL32025: Protein synthesis, folding, structure-function and turnover

[Page last updated: 15 May 2025]

Academic Year: 2025/26
Owning Department/School: Department of Life Sciences
Credits: 10 [equivalent to 20 CATS credits]
Notional Study Hours: 200
Level: Honours (FHEQ level 6)
Period:
Academic Year
Assessment Summary: CWRI 40%, EXCB 60%
Assessment Detail:
  • Closed book written examination (EXCB 60%)
  • Report Individual (CWRI 40%)
Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Requisites:
Learning Outcomes: At the end of this unit, you will be able to: 1. Demonstrate your understanding of the molecular mechanisms underpinning the translation of genetic information into proteins. 2. Describe the basic structure and function of prokaryotic ribosomal translation and explain at a molecular level the various ways antibiotics can interfere with this process. 3. Explain the principles of protein folding in pro- and eukaryotic systems. 4. Describe post-translational modifications and their link with protein folding. 5. Discuss the relationship between protein 3D structure and function. 6. Demonstrate a critical understanding of protein misfolding and the processes involved in protein degradation.


Synopsis: You will develop a detailed understanding of the life cycle of proteins at a molecular level from their synthesis, by ribosomes, through the processes involved in their three-dimensional folding and the relationship between protein structure and function, and finally, the mechanisms involved in protein degradation. You will conduct a bioinformatical analysis of a family of proteins involved in the process of protein synthesis.

Content: This unit will explore in detail the current understanding of how proteins are produced and processed in pro- and eukaryotic systems, and how protein structure relates to their function. The molecular mechanisms underpinning the translation of genetic information into proteins, how proteins fold and are post-translationally modified, and their 3D structure will be covered. The impact of these processes on clinical scenarios will include a critical consideration of antibiotic actions on prokaryotic ribosomal systems and the consequences of protein misfolding and aberrant degradation in disease states.

Course availability:

SL32025 is Compulsory on the following courses:

Department of Chemistry
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry) (Year 3)
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science) (Year 3)
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Year long work placement (Year 4)
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 3)
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry) (Year 3)
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Year long work placement (Year 4)
  • USSC-AFM10 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 4)
  • USSC-AFM10 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Professional Placement (Year 4)
  • USSC-AFM10 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 4)
Department of Life Sciences
  • USSL-AFB10 : BSc(Hons) Biochemistry (Year 3)
  • USSL-AKB01 : BSc(Hons) Biochemistry with Professional Placement (Year 4)
  • USSL-AFM10 : MBiochem(Hons) Biochemistry (Year 3)
  • USSL-AKM01 : MBiochem(Hons) Biochemistry with Professional Placement (Year 4)

SL32025 is Optional on the following courses:

Department of Chemistry
  • USSC-AFB10 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Year long work placement (Year 4)
  • USSC-AFM10 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 4)
Department of Life Sciences
  • USSL-AFB12 : BSc(Hons) Biomedical Sciences (Year 3)
  • USSL-AKB03 : BSc(Hons) Biomedical Sciences with Professional Placement (Year 4)
  • USSL-AFM12 : MBiomed(Hons) Biomedical Sciences (Year 3)
  • USSL-AKM03 : MBioMed(Hons) Biomedical Sciences with Professional Placement (Year 4)

Notes:

  • This unit catalogue is applicable for the 2025/26 academic year only. Students continuing their studies into 2026/27 and beyond should not assume that this unit will be available in future years in the format displayed here for 2025/26.
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