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CH40206: Topics in organic chemistry II

[Page last updated: 23 April 2025]

Academic Year: 2025/26
Owning Department/School: Department of Chemistry
Credits: 3 [equivalent to 6 CATS credits]
Notional Study Hours: 60
Level: Masters UG & PG (FHEQ level 7)
Period:
Semester 1
Assessment Summary: EX 100%
Assessment Detail:
  • Exam (EX 100%)
Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Requisites: Before taking this module you must take CH20149 OR take CH20150
Learning Outcomes: After studying this unit students should be able to:
* Understand the factors that affect the structure, stability, and reactivity of radicals;
* Describe why radical chemistry is useful in synthesis;
* Explain the mechanisms of both chain and non-chain radical processes;
* Appreciate the catalysis modes that are relevant to radical-based reactions;
* Apply the information learned to solve unseen problems in radical chemistry selected from contemporary research literature.


Content: 1. Fundamentals of radical structure, stability, and reactivity.
2. Methods for radical generation.
3. Radical chain reactions (with and without Bu3SnH).
4. Additions of radicals to alkenes.
5. C-H bond functionalisations.
6. Redox reactions via radical intermediates.
7. HAT (hydrogen atom transfer) catalysis.
8. Redox catalysis with transition metals.
9. Photoredox catalysis.
10. Mergers of different catalysis strategies.

Skills: Problem solving (T, F, A)
Scientific writing (F, A), Independent working (F)
Group working (F)

Aims: The aim of the unit is to give students a thorough grounding in the fundamental reactivity of radicals, and the most important radical-mediated reactions in organic synthesis. It will also introduce modern catalysis concepts that are applicable to reactions proceeding via radical intermediates.

Course availability:

CH40206 is Compulsory on the following courses:

Department of Chemistry
  • USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 4)
  • USCH-AFM05 : MChem(Hons) Chemistry for Drug Discovery (Year 4)
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)
  • USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 4)

CH40206 is Optional on the following courses:

Department of Chemistry
  • USCH-AFM02 : MChem(Hons) Chemistry (Year 4)
  • USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 4)
  • USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 5)

Notes:

  • This unit catalogue is applicable for the 2025/26 academic year only. Students continuing their studies into 2026/27 and beyond should not assume that this unit will be available in future years in the format displayed here for 2025/26.
  • 好色tv and units are subject to change in accordance with normal University procedures.
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  • Find out more about these and other important University terms and conditions here.